Wednesday, October 01, 2008


This could be world changing, patent pending at the moment though....

(WO/2008/010082) DIAGNOSTIC METHOD FOR FIBROMYALGIA (FMS) OR CHRONIC FATIGUE SYNDROME (CFS): "The invention relates to methods for the diagnosis, prognosis and treatment of Fibromyalgia (FM or FMS) and Chronic fatigue syndrome (CFS) and to products for use therein.

Background of the invention

FMS (code G93.3) and CFS (code M 79.0) are considered as two different diseases based on the International Classification of Diseases (ICD-10) supported by The World Health Organization (WHO).

There is some overlap in symptomology between the diseases: bodily pain, chronic fatigue, unrefreshing sleep, mood disorders, irritable bowel; but the diseases have different clinical presentation profiles, as well as different criteria for case definition, prevalence and prognoses. A detailed clinical history, a full physical exploration and some complementary biochemistry test (routine analysis in blood and urine: a complete blood count with differential, C-reactive protein, alanine aminotransferase, albumin) allow physicians to provide a clinical diagnosis based on: -FMS: Clinical criteria of the American College of Rheumatology (1990)18 (ACR'90). -CFS: Clinical criteria of the Center for Disease Control and Prevention (19Fukuda et. al 1994) (CDC94).

Summary of the invention

The present inventors have identified positions of single nucleotide polymorphism (SNPs) which can be used for reliably determining FMS and CFS phenotypes. Accordingly the present invention provides a method of diagnosing or prognosing a fibromyalgia syndrome (FMS) or chronic fatigue syndrome (CFS) phenotype in a subject.....The invention also provides a method of selecting a suitable treatment for treating FMS or CFS in a subject, and a method of treating FMS or CFS in a subject as set out in the present claims."

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