Treatment of Fibromyalgia Open Trial of Pindolol

Shows improvement in Tender Point Count Open Trial of Pindolol in the Treatment of Fibromyalgia: "Open Trial of Pindolol in the Treatment of Fibromyalgia ImmuneSupport.com

BACKGROUND: Evidence suggests that fibromyalgia is related to both chronic sympathetic hyperactivity and decreased levels of serotonin.

OBJECTIVE: To examine the efficacy of pindolol, a mixed serotonin (5-HT)1A presynaptic autoreceptor/beta-adrenergic receptor antagonist, in the treatment of fibromyalgia.

RESULTS: There was significant improvement in primary outcome measures, including Tender Point Count ..

depression and anxiety scores did not change significantly among women who completed the study, while the impact on cardiovascular parameters was clinically insignificant.

CONCLUSIONS: While the current results are encouraging, further studies are needed to determine whether pindolol might be effective in the treatment of fibromyalgia. Limitations of this study include small group size and lack of placebo control."