"Attention is drawn to a recent paper which serves to confirm that multiple chemical sensitivity (MCS), a well-documented component of myalgic encephalomyelitis (ME), is not a somatoform disorder or any other kind of psychiatric disorder as asserted by certain psychiatrists, most notably those of the Wessely School.
The paper (Biological definition of multiple chemical sensitivity from redox state and cytokine profiling and not from polymorphisms of xenobiotic-metabolizing enzymes; De Luca C et al: Toxicol. Appl. Pharmacol 2010; doi:10.1016/j.taap.2010.04.017) supports the work of Professor Emeritus of Biochemistry and Basic Medical Sciences at Washington State University, Martin Pall, who proposed that MCS is caused by toxic chemical exposure leading to toxic brain injury.
Based on the results obtained, the authors suggest that the serious and multiple dysfunctions of the chemical defence system found in MCS patients may not depend on genetic defects but on non-genetic modifications of metabolising/antioxidant enzyme expression and/or activity. They conclude that MCS is characterised by a number of biochemical and immunological disturbances and that these metabolic and immunological parameters should be taken into consideration in both the biological and clinical/laboratory diagnosis of MCS."